“PIXYISH” is a valid word. — 22 points Scrabble

pyxisfruit of such plants as the plantain; a capsule whose upper part falls off when the seeds are released

shipa vessel that carries passengers or freight
hipseither side of the body below the waist and above the thigh
pish
pixycreeping evergreen shrub having narrow overlapping leaves and early white star-shaped flowers; of the pine barrens of New Jersey and the Carolinas
yipsnervous tension that causes an athlete to fail (especially causes golfers to miss short putts)
sypha common venereal disease caused by the treponema pallidum spirochete; symptoms change through progressive stages; can be congenital (transmitted through the placenta)
phisthe 21st letter of the Greek alphabet
hyps

his
sixthe cardinal number that is the sum of five and one
spy(military) a secret agent hired by a state to obtain information about its enemies or by a business to obtain industrial secrets from competitors
shya quick throw
hipeither side of the body below the waist and above the thigh
sipa small drink
yipa sharp high-pitched cry (especially by a dog)
psia unit of pressure
phithe 21st letter of the Greek alphabet
pixa chest in which coins from the mint are held to await assay
pis
hyp
xis
pyxa chest in which coins from the mint are held to await assay

ishave the quality of being; (copula, used with an adjective or a predicate noun)
hian expression of greeting
sia tetravalent nonmetallic element; next to oxygen it is the most abundant element in the earth's crust; occurs in clay and feldspar and granite and quartz and sand; used as a semiconductor in transistors
sh
pithe ratio of the circumference to the diameter of a circle; approximately equal to 3.14159265358979323846...
xithe cardinal number that is the sum of ten and one

PIXYISH